When a cigarette burns, nicotine is released in the form of a vapour that collects and condenses on indoor surfaces such as walls, carpeting, drapes and furniture, where it can linger for months, said the study, which was published in the Proceedings of the National Academy of Sciences (PNAS).
"Our study shows that when this residual nicotine reacts with ambient nitrous acid it forms carcinogenic tobacco-specific nitrosamines, or TSNAs," said Hugo Destaillats, a corresponding author of the study.
"TSNAs are among the most broadly acting and potent carcinogens present in unburned tobacco and tobacco smoke," he said.
The most likely human exposure to TSNAs is through either inhalation of dust or the contact of skin with carpet or clothes - making third-hand smoke particularly dangerous to infants and toddlers.
Opening a window or turning on a fan to air out a room while a cigarette burns does not eliminate the hazard of third-hand smoke. Smoking outdoors doesn't help much either.
"Those residues follow a smoker back inside and get spread everywhere. The biggest risk is to young children," she said.
"Dermal uptake of the nicotine through a child's skin is likely to occur when the smoker returns and if nitrous acid is in the air, which it usually is, then TSNAs will be formed."
Researchers from the Lawrence Berkeley National Laboratory led the study, which they say is the first to quantify the reactions of third-hand smoke with nitrous acid.
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